Premium
Diminution de la synthèse de NO en présence de parodontite
Author(s) -
Aurer Andrej,
Aleksić Jos˘ko,
IvićKardum Marija,
Aurer Jelena,
Čulo Filip
Publication year - 2001
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2001.028006565.x
Subject(s) - periodontitis , nitric oxide , medicine , dentistry , chemistry
Objectives: In order to study the possible rôle of nitric oxide (NO) in the development of periodontitis, we measured the concentration of its stable metabolite nitrite (NO 2 − ) in the saliva of patients with periodontitis and healthy subjects. Materials and methods: We have analysed salivary NO 2 − concentrations in 25 subjects with rapidly progressive periodontitis (RPP), 25 with adult periodontitis (AP) and in 25 periodontally‐healthy persons. The concentrations of NO 2 − were determined by the Griess reaction in microtitration plates. Periodontal tissue destruction was determined by measuring the attachment level loss using standard methods. Results: Subjects with periodontitis had significantly less NO 2 − in saliva than healthy subjects. Subjects with RPP had lower NO 2 − concentrations than those with AP. Parotid gland saliva contained less NO 2 − than sublingual gland or total saliva. Conclusions: Local NO production is decreased in patients with periodontitis. This effect is more pronounced in those with severe types of disease.