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Microbiology of destructive periodontal disease in adolescent patients with congenital neutropenia
Author(s) -
Winkelhoff A. J.,
Schoutenvan Meeteren A. Y. N.,
Baart J. A.,
VandenbrouckeGrauls C. M. J. E.
Publication year - 2000
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2000.027011793.x
Subject(s) - actinobacillus , porphyromonas gingivalis , gingivitis , periodontitis , medicine , neutropenia , congenital neutropenia , periodontal disease , microbiology and biotechnology , dentistry , immunology , biology , toxicity
Background, aims: Congenital neutropenia is one condition that may predispose for destructive periodontal disease at a young age. In this report, we describe the microbiology of 3 adolescent patients with congenital neutropenia two of whom suffered from severe periodontitis. Method: Microbiological testing of the parents was also performed in 1 case. DNA fingerprinting was used to study transmission of putative periodontal pathogens in this case. From 1 patient with periodontitis, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were isolated; a 2nd periodontitis patient was infected with P. gingivalis. A 3rd patient had gingivitis only and no A. actinomycetemcomitans or P. gingivalis were found. Results: Using the amplified fragment length polymorphism DNA fingerprinting technique, bacterial transmission between the father and a patient was shown for A. actinomycetemcomitans but not for P. gingivalis.