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Fcα receptor I (CD89) on neutrophils in periodontal lesions
Author(s) -
Yuan ZuanNing,
Gjermo Per,
Helgeland Kristen,
Schenck Karl
Publication year - 2000
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2000.027007489.x
Subject(s) - connective tissue , periodontitis , medicine , junctional epithelium , pathology , gingival and periodontal pocket , gingivitis , gingival margin , chronic periodontitis , dentistry
Aims: In this study, we have examined the occurence of FcαRI‐bearing cells in gingival tissue, gingival fluid and blood, in search for possible roles of IgA and FcαRI in periodontal lesions. Methods: Gingival biopsies from inflamed and healthy sites were obtained from patients with chronic marginal periodontitis. Sections of inflamed gingiva were examined by immunofluorescence techniques and compared to sections from healthy sites. Smears were made from blood and gingival crevicular fluid and similarly studied. Results: Dense infiltrates of neutrophils with strong expression of FcαRI (and FcγRIII) were found in connective tissue and epithelium of the apical part of periodontal pockets from diseased sites. In contrast, only few such cells were found in healthy gingiva from the same patients. Neutrophils in gingival fluid, tissue and blood expressed FcαRI with similar intensity, whereas the expression of FcγRIII was significantly decreased in gingival crevicular fluid. Considerable numbers of bacteria from gingival plaque were found to be covered by IgA. Conclusion: It is suggested that FcαRI on neutrophils may play an important rôle in elimination of IgA‐opsonized bacteria, both in periodontal tissue and the adjacent pockets.