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Laser Doppler flowmeter measurement of relative gingival and forehead skin blood flow in light and heavy smokers during and after smoking
Author(s) -
Meekin T. N.,
Wilson R. F.,
Scott D. A.,
Ide M.,
Palmer R. M.
Publication year - 2000
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2000.027004236.x
Subject(s) - cotinine , medicine , blood flow , forehead , laser doppler velocimetry , nicotine , relative risk , surgery , confidence interval
Aim: To determine the effect of the smoking experience on relative blood flow in gingiva and to compare this to skin. Method: A laser Doppler flowmeter was used to record relative blood flow to healthy gingiva and to forehead skin in smokers and non‐smoking controls. Smoking status was verified by quantitative analysis of serum cotinine. Continuous measurements were made over sequential periods with the subject at rest, during a sham smoking exercise, during smoking of a standard research cigarette (2R1, University of Kentucky) for 5 min and throughout a subsequent recovery period. Non‐smoking controls sham smoked during the equivalent 5 minute smoking period. Results: No significant differences with respect to the proportional changes of relative gingival blood flow between time points were observed between the groups. However, between‐group comparisons of relative blood flow revealed a significant increase in the relative blood flow to the forehead skin of light smokers (serum cotinine 60 ng/ml; n =6), when compared to heavy smokers (serum cotinine 100 ng/ml; n =9) or to non‐smokers (serum cotinine 10 ng/ml; n =6), 2 min following the smoking experience ( p =0.007). Conclusion: The results do not seem to support the theory that tobacco smoking causes localised vasoconstriction in the periodontal tissues in humans. These data show that smoking causes an acute increase in relative blood flow in forehead skin in light smokers compared to heavy smokers, suggesting a potential induction of tolerance in regular users of tobacco.