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Periodontal flap surgery with 25% metronidazole gel
Author(s) -
Needleman Ian G.,
Moles David R.,
Collins Angela M.
Publication year - 2000
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2000.027003193.x
Subject(s) - medicine , metronidazole , bleeding on probing , periodontal surgery , periodontitis , gingival and periodontal pocket , dentistry , chronic periodontitis , gastroenterology , surgery , antibiotics , microbiology and biotechnology , biology
Objectives: The aim of this study was to examine the effect of periodontal surgery on PGE 2 levels in patients treated for advanced adult periodontitis, with and without application of a 25% metronidazole gel over 12 months follow‐up. Material and methods: The trial employed a randomised controlled, single‐blind, parallel arm design on 43 patients with at least 1 pocket probing 6 mm with bleeding on probing (BOP). Results: The results showed that GCF PGE 2 levels showed no significant change following surgical therapy despite marked improvements in clinical periodontal health ( p =0.653). No significant differences in the reaction of sites to treatment were detected between test and control groups throughout the study ( p =0.709). However, PGE 2 levels in GCF were significantly higher in experimental sites compared with healthy untreated sites (negative controls) in both surgery only ( p =0.001) and surgery+gel ( p =0.023) groups throughout the study. Conclusion: Whilst clear differences were observed between healthy control sites and sites with periodontal breakdown, no effect of treatment on PGE 2 levels was discernible in this study.