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After‐effects of stress on crevicular interleukin‐1ß
Author(s) -
Deinzer Renate,
Kottmann Wulf,
Förster Peter,
Herforth Armin,
StillerWinkler Renate,
Idel Helga
Publication year - 2000
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2000.027001074.x
Subject(s) - gingivitis , medicine , dentistry , periodontium , oral hygiene , stress (linguistics) , interleukin , physiology , cytokine , philosophy , linguistics
Background: In a previous study, we found stress to increase crevicular interleukin‐1ß (Il‐1ß) secretion induced by supragingival plaque. While in that study, stress and plaque were presented concomitantly, we now wondered whether a consecutive presentation of these 2 factors would still exert stress effects. Method: 39 medical students participated in the study; 18 took part in a major exam while the remaining 21 served as controls. From the day after the last exam, students neglected oral hygiene in 2 antagonistic quadrants for 21 days (experimental gingivitis), while they maintained perfect hygiene at the remaining sites. Crevicular fluid samples were taken at days 0, 5, 8, 15, 18, and 21 of experimental gingivitis. Results: A significant effect of pre‐exposure to academic stress on crevicular Il‐1ß concentration was found (area under the curve: p =0.042), the effect size, however, being smaller than in our previous study when stress and plaque were presented concomitantly. Conclusions: It is concluded that pre‐exposure to stress may persistently alter the immunological effects of microbial challenge to the periodontium.