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Effects of smoking on local delivery of controlled‐release doxycycline as compared to scaling and root planing
Author(s) -
Ryder Mark I.,
Pons Barbara,
Adams Donald,
Beiswanger Bradley,
Blanco Valerie,
Bogle Gary,
Donly Kevin,
Hallmon William,
Hancock E. Brady,
Hanes Philip,
Hawley Charles,
Johnson Lonnie,
Wang HomLay,
Wolinsky Lawrence,
Yukna Raymond,
Polson Alan,
Carron Graham,
Garrett Steven
Publication year - 1999
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.1999.261008.x
Subject(s) - medicine , scaling and root planing , doxycycline , dentistry , bleeding on probing , antibiotics , periodontitis , chronic periodontitis , microbiology and biotechnology , biology
. This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled‐release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9‐month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (≥10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths ≥5 mm and for a subset of treated sites with baseline probing depths of ≥7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non‐smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled‐release of locally‐delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.