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Comparative antimicrobial activity of an essential oil and an amine fluoride/stannous fluoride mouthrinse in vitro
Author(s) -
Pan P. H.,
Finnegan M. B.,
Sturdivant L.,
Barnett M. L.
Publication year - 1999
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.1999.260710.x
Subject(s) - fluoride , antimicrobial , in vitro , chemistry , microbiology and biotechnology , dentistry , medicine , organic chemistry , biology , biochemistry , inorganic chemistry
. Although laboratory studies are not necessarily predictive of clinical activity, they can help to elucidate mechanisms underlying clinical activity when the latter has been established. In a recent clinical study, an essential oil mouthrinse (Listerine® Antiseptic) was shown to be significantly more effective than an amine fluoride/stannous fluoride mouthrinse (Meridol®) in inhibiting supragingival plaque formation. This paper reports the results of laboratory studies comparing the antimicrobial effectiveness of these 2 mouthrinses using a kill kinetics assay and a plaque biofilm kill assay. In both assays, the essential oil mouthrinse was considerably more effective than the amine fluoride/stannous fluoride mouthrinse. These findings are consistent with the results of the clinical trial and may help to explain the observed differences in clinical activity.