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Gingival crevicular fluid osteocalcin in adult periodontitis
Author(s) -
Lee Allison J.,
Walsh Trevor F.,
Hodges Stephen J.,
Rawlinson Andrew
Publication year - 1999
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.1999.260409.x
Subject(s) - osteocalcin , periodontitis , medicine , dentistry , gingival sulcus , clinical attachment loss , bleeding on probing , periodontal disease , chemistry , alkaline phosphatase , biochemistry , enzyme
. This study aimed to detect the levels of osteocalcin in gingival crevicular fluid (GCF) from healthy (≤3 mm sulcus depth and non‐bleeding) and diseased sites (≥6 mm probing depth and bleeding) in subjects with adult periodontitis, in order to further investigate its potential as a possible marker of the disease process. Periodontal probing depths, attachment levels and gingival indices were recorded from one healthy and one diseased site in each of 20 subjects with adult periodontitis. Both GCF accumulated in the periodontal pocket or sulci and GCF flowing into the periodontal pocket or sulci over a three‐minute interval were sampled. The amounts of osteocalcin in each GCF sample was determined using immunoassays. A mean of 2.34 ng/site (2.7 μg/ml) osteocalcin was found at diseased sites and a mean of 2.47 ng/site (5.47 μg/ml) was found at healthy sites for the accumulated GCF collection method. A mean of 0.17 ng/site (2.17 μg/ml) osteocalcin was found at diseased sites and a mean of 0.14 ng/site (1.85 μg/ml) at healthy sites for the flow method of GCF collection. There were no statistically significant differences between osteocalcin levels in diseased and healthy sites in subjects with adult periodontitis.