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Increase of crevicular interleukin 1b under academic stress at experimental gingivitis sites and at sites of perfect oral hygiene
Author(s) -
Deinzer R.,
Förster P.,
Fuck L.,
Herforth A.,
StillerWinkler R.,
Idel H.
Publication year - 1999
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.1999.260101.x
Subject(s) - gingivitis , oral hygiene , dentistry , medicine , hygiene , pathology
Abstract . This study analyses the effects of academic stress on crevicular interleukin‐1b (Il‐1β) both at experimental gingivitis sites and at sites of perfect oral hygiene. Il‐1β is thought to play a predominant role in periodontal tissue destruction. 13 medical students participating in a major medical exam (exam group) and 13 medical students not participating in any exam throughout the study period (control group) volunteered for the study. In a split‐mouth‐design, they refrained from any oral hygiene procedures in two opposite quadrants for 21 days (experimental gingivitis) while they maintained perfect hygiene levels at the remaining sites. Crevicular fluid was sampled for further Il‐1b analysis at teeth 5 and 6 of the upper jaw at days 1, 5, 8, 11, 14, 18 and 21 of the experimental gingivitis period. Exam students showed significantly higher Il‐1b levels than controls both at experimental gingivitis sites (area under the curve, exam group: 1240.64±140.07; control group: 697.61±111.30; p =0.004) and at sites of perfect oral hygiene (exam group: 290.42±63.19; control group: 143.98±42.71; p =0.04). These results indicate that stress might affect periodontal health by increasing local Il‐1β levels especially when oral hygiene is neglected.