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Controlled local application of basic fibroblast growth factor (FGF‐2) accelerates the healing of GBR
Author(s) -
Hosokawa Ryuji,
Kikuzaki Kenji,
Kimoto Tomohide,
Matsuura Takashi,
Chiba Daisuke,
Wadamoto Masayoshi,
Sato Yuuji,
Maeda Miho,
Sano Akihiko,
Akagawa Yasumasa
Publication year - 2000
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1034/j.1600-0501.2000.011004345.x
Subject(s) - fibroblast growth factor , beagle , microgram , regeneration (biology) , medicine , basic fibroblast growth factor , placebo , growth factor , anatomy , dentistry , pathology , chemistry , microbiology and biotechnology , biology , in vitro , biochemistry , receptor , alternative medicine
This animal study was performed to ascertain whether the regeneration of membrane‐protected bone defects can be accelerated by the controlled application of basic fibroblast growth factor (FGF‐2) using a new drug delivery system. Standardized alveolar bone defects were made surgically in 9 beagle dogs, and FGF‐2 was administered using specially made collagen minipellets. A minipellet containing either 0.15 μg FGF‐2 (FGF) or 0 μg FGF‐2 (placebo) was placed in the defect or no minipellet was used (control), and bone regeneration was evaluated radiologically, histologically, and histometrically 8 weeks after the operation. Radiographs showed a surprisingly large radiopaque region in FGF sites compared with placebo or control sites. Histologically, mature bone filled the majority of the inner space of the membrane‐protected defect in FGF sites. New bone formation was also seen in the control and the placebo sites, however, it filled less than half the area of the defect. Histometrically, the area of regenerated bone in FGF sites was significantly higher than in the other sites ( P <0.01). These results demonstrate that the controlled application of FGF‐2 accelerates bone regeneration in membrane‐protected bone defects in the canine model.