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Fixed implant‐supported prostheses in the edentulous maxilla. A five‐year follow‐up report.
Author(s) -
Weber H. P.,
Fiorellini J. P.,
Paquette D. W.,
Howell T. H.,
Williams R. C.
Publication year - 1994
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1034/j.1600-0501.1994.050305.x
Subject(s) - beagle , medicine , dentistry , implant , peri implantitis , dental alveolus , flurbiprofen , radiography , oral hygiene , bone resorption , placebo , surgery , anesthesia , alternative medicine , pathology
There is increasing interest in how pathways of tissue destruction around dental implants are similar as for teeth and how these pathways can be modulated to slow loss of supporting bone. The purposes of this study were to develop a short‐term animal model to study the effect of the nonsteroidal anti‐inflammatory drug flurbiprofen, on slowing the rate of induced peri‐implant bone resorption. A total of 20 cylindrical titanium implants were placed in 2 beagle dogs using a low‐trauma surgical technique. During the 3‐month healing period without functional loading of the implants, daily oral hygiene was performed to maintain a Gingival Index of 0 to 0.5. At completion of the healing period, a baseline evaluation was performed which included the uptake of the bone‐seeking radiopharmaceutical (BSRU) 99m technetium‐tin‐diphosphonate ( 99m Tc‐Sn‐MDP) in peri‐implant bone and standardized radiographs. Peri‐implantitis was induced with 4‐O silk ligatures, cessation of oral hygiene and soft diet. One beagle was given 0.02 mgikg of flurbiprofen by mouth; the other received a placebo. BSRU and radiographic height of bone were remeasured to calculate the rate of bone loss during the 60‐day treatment period. The percent rate of bone loss during the study period was calculated from the radiographs using a computer‐assisted method. The radiopharmaceutical uptake for the flurbiprofen‐treated implants remained unchanged. However, BSRU for placebo‐treated implants was significantly increased from baseline. Radiographic measurements of bone height revealed that the mean rate of bone loss around implants in the flurbiprofen‐treated dog (0.066±0.351%/month) was significantly lower than the rate around implants in the placebo‐treated dogs (5.729±0.384%/month) over the 60‐day treatment period. These data indicate that peri‐implant bone loss can be rapidly induced and measured in the beagle and that flurbiprofen. administered orally, can significantly decrease the rate of induced peri‐implant bone loss.