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Dendritic cells in peripheral tolerance and immunity
Author(s) -
GAD MONIKA,
CLAESSON MOGENS HELWEG,
PEDERSEN ANDERS ELM
Publication year - 2003
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2003.11107808.x
Subject(s) - microbiology and biotechnology , immunity , peripheral tolerance , in vitro , biology , function (biology) , immunology , immune tolerance , dendritic cell , in vivo , immune system , genetics
Dendritic cells capable of influencing immunity exist as functionally distinct subsets, T cell‐tolerizing and T cell‐immunizing subsets. The present paper reviews how these subsets of DCs develop, differentiate and function in vivo and in vitro at the cellular and molecular level. In particular, the role of DCs in the generation of regulatory T cells is highlighted.