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Uncoupling activation‐induced modulation of CD16 and CD69 in CD56+ cells during AIDS
Author(s) -
Barboza José M.,
Salmen Siham,
Cova José A.,
Albarrán Benibelks,
Goncalves Loredana,
Borges Lérida,
Hernández Manuel,
Berrueta Lisbeth
Publication year - 2002
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2002.100508.x
Subject(s) - cd16 , asymptomatic , downregulation and upregulation , immunology , immune system , innate immune system , medicine , immunopathology , cd69 , immunity , receptor , cd3 , biology , t cell , cd8 , il 2 receptor , biochemistry , gene
The immune system of HIV+ patients is chronically activated, which has been associated with a detrimental effect on both innate and acquired immunity during AIDS. We analyzed the expression and modulation of the triggering markers CD69 and CD16 in CD56 + cells from 18 asymptomatic HIV+ individuals and 8 AIDS patients, compared with 21 seronegative subjects. We observed a diminished PMA‐induced CD16 downregulation in AIDS patients (p<0.01), associated with low numbers of CD4 + cells (p<0.02). Furthermore, an enhanced unstimulated expression of CD69 in asymptomatic HIV+ patients (p<0.05) was shown. AIDS patients could not efficiently upregulate PHA‐dependent CD69 expression (p<0.05), which correlated with low CD4 + counts (p< 0.05). These abnormalities in CD16 and CD69 modulation were recorded in patients under highly active antiretroviral therapy (HAART). Our results demonstrate an altered modulation of two functionally relevant receptors in CD56 + cells from AIDS patients, contributing to our understanding of the immunopathogeny of NK cell dysfunction during disease progression.