Premium
Histologic changes in thyroid nodules after percutaneous ethanol injection in patients subsequently operated on due to new focal thyroid lesions
Author(s) -
Pomorski Lech,
Bartos Magdalena
Publication year - 2002
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2002.100208.x
Subject(s) - medicine , percutaneous ethanol injection , thyroid nodules , nodule (geology) , thyroid , malignancy , biopsy , radiology , fibrosis , histopathological examination , fine needle aspiration , pathology , paleontology , radiofrequency ablation , ablation , biology
This paper reports macro‐ and microscopic changes in hyperfunctioning thyroid nodules (HTN), initially diagnosed as solitary, in patients treated with percutaneous ethanol injection (PEI). In 78 patients, benign solitary HTN were diagnosed by clinical and hormonal examination. High resolution ultrasonography confirmed the solitary nodule. The results of fine needle aspiration biopsy (FNAB), performed twice, ruled out malignancy of the nodule. The patients were referred for PEI treatment. At 1‐year follow‐up, newly formed thyroid nodules, whose volumes increased, were detected in five patients (6.4%) with HTN, initially diagnosed as solitary. Therefore, these patients were operated on. Subtotal thyroidectomy was performed. At the intraoperative macroscopic evaluation, a hard fibrous solid mass was found in place of three nodules (n 1 , n 2 , n 3 ) following PEI treatment. The middle area of the cut surface of PEI‐treated nodules (n 4 and n 5 ) in the other two patients was firm and haemorrhagic, surrounded by a fibrous mass. Histolopathologic examination of n 1 , n 2 and n 3 revealed fibrosis and hyalinosis. Examination of n 4 and n 5 showed haemorrhagic necrosis in the middle of the nodules surrounded by fibrous tissue.