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p 53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum
Author(s) -
Jiao YuFei,
Nakamura ShinIchi,
Sugai Tamotsu,
Habano Wataru,
Uesugi Noriyuki,
Oikawa Moriyasu,
Sato Tsukasa
Publication year - 2002
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2002.100207.x
Subject(s) - vimentin , jejunum , pathology , exon , missense mutation , immunohistochemistry , carcinogenesis , mutation , intussusception (medical disorder) , biology , nonsense mutation , gene , gene mutation , cancer research , medicine , genetics , surgery , endocrinology
Primary malignant fibrous histiocytoma of the gastrointestinal tract is extremely rare. To date, only 10 cases of primary malignant fibrous histiocytoma arising in the small intestine have been reported in the English literature. We describe here the genetic alterations and morphologic features of a primary malignant fibrous histiocytoma arising in the jejunum. Immunohistochemically, the tumor cells expressed vimentin, CD68 and α‐1‐antitrypsin, but were negative for other markers. Ultrastructurally, they showed features of fibroblasts and histiocytes. Immunohistochemical overexpression of p53 and MDM2 was observed. Mutation analysis of the p 53 gene detected a missense mutation in codon 158 of exon 5. Our results suggest that p 53 gene mutations and MDM2 overexpression may play an important role in the tumorigenesis. To our knowledge, the present report is the first genetic study of this rare lesion.