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Benign solitary fibrous pleural tumour. Evidence of primitive features and complex genomic imbalances, including loss of 20q Note
Author(s) -
AMOTAKYI B. K.,
GÜNTHER K.,
PETERS I.,
MITTERMAYER C.,
EBLENKAMP M.,
TIETZE L.
Publication year - 2001
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2001.d01-181.x
Subject(s) - immunohistochemistry , comparative genomic hybridization , vimentin , biology , pathology , cd34 , solitary fibrous tumor , ultrastructure , intermediate filament , microbiology and biotechnology , chromosome , anatomy , cell , genetics , gene , medicine , immunology , stem cell , cytoskeleton
Aims: Cytogenetic data on solitary fibrous tumours (SFT) are very limited. We studied a benign pleural SFT for its ultrastructural and immunohistochemical details, and made cytogenetic analyses for comparison with other genetic and ultrastructural studies of SFT. Results: Immunohistochemistry showed strong positivities for CD34 and vimentin, but no reactions with anti‐cytokeratins and epithelial membrane antigens. Electron microscopy revealed primitive desmosomes in our SFT. The results thus evinced fibroblast‐like cells with intermediate epithelial‐mesenchymal character. Comparative genomic hybridization of the tumour revealed losses of 1p33→pter, 17pter–q21, entire copies of chromosomes 19 and 22, and gains of 1p21–p22, 2q23–q32.3, 3p12–q13.2, 4p14–q28, 6p12–q21, 9p21→pter and 13q21–q31. Furthermore, there was loss of 20q, as was previously reported elsewhere in a case of benign and a case of malignant SFT. Conclusions: The results furnish further evidence of the involvement of −20q in SFT. In addition, they show that SFT may have complex genomic imbalances and primitive features, despite having a benign appearance.