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Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis Note
Author(s) -
Nevalainen Timo J.,
Shah Varsha I.,
De PeraltaVenturina Mariza,
Amin Mahul B.
Publication year - 2001
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2001.d01-123.x
Subject(s) - paneth cell , metaplasia , in situ hybridization , epididymis , immunohistochemistry , epithelium , lysozyme , cell , biology , goblet cell , cytoplasm , pathology , messenger rna , sperm , microbiology and biotechnology , endocrinology , immunology , medicine , biochemistry , gene , small intestine , botany
Paneth cell‐like metaplasia has been reported in the epithelium of the epididymis and prostatic adenocarcinomas. We studied the expression of group II phospholipase A2 (PLA2), a marker of Paneth cell differentiation, in six orchiectomy specimens with Paneth cell‐like metaplasia. Both immunohistochemistry for group II PLA2 protein and in situ hybridization for the mRNA of group II PLA2 gave negative results in all six cases but positive reaction for lysozyme. The results show that the cells of the Paneth cell‐like metaplasia are not true Paneth cells.