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Allele 2 of interleukin‐1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis
Author(s) -
Luotola K.,
Mantula P.,
Salmi J.,
Haapala A.M.,
Laippala P.,
Hurme M.
Publication year - 2001
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2001.090608.x
Subject(s) - medicine , endocrinology , thyroiditis , thyroglobulin , thyroid peroxidase , interleukin 1 receptor antagonist , allele , erythrocyte sedimentation rate , thyroid , allele frequency , receptor antagonist , immunology , biology , receptor , antagonist , gene , genetics
Subacute granulomatous thyroiditis (SAT) is a self‐limiting systemic inflammatory disorder with possible transient expression of thyroid antibodies. Persistent hypothyroidism is uncommon. The interleukin‐1 receptor antagonist IL‐1ra is an inhibitor of IL‐1 activity and allele 2 of the IL‐1ra gene is associated with inflammatory diseases and IL‐1ra production. Forty‐eight subjects with SAT were investigated. Polymorphisms of IL‐1ra, IL‐1β‐511 and TNFα genes were studied with respect to thyroid peroxidase antibodies (TPOab), thyroglobulin antibodies, C‐reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Serum IL‐1ra levels were measured. An increased allelic frequency (43% vs 22%, p=0.039) and carriage rate (79% vs 41%, p=0.018) for IL‐1ra allele 2 were observed with expression of TPOab in 14 (29.2%) subjects compared with those with negative findings. The carriage rate for both IL‐1ra allele 2 and IL‐1β‐511 allele 2 was also increased with TPOab expression (71% vs 27%, p=0.004, respectively). No difference in allele frequency or carriage rate was found compared with healthy controls. Serum IL‐1ra levels correlated with S‐CRP (r=0.41, p=0.004) and ESR (r=0.34, p=0.016), but the association with genes or thyroid antibodies was statistically insignificant. S‐CRP levels and ESR were lower and negatively correlated with expression of TPOab (r=−0.27, p=0.046 and r=−0.32, p=0.017). This study describes the multiplicity of the mechanisms responsible for the severity of the acute‐phase response during the course of SAT. IL‐1ra may have a significant anti‐inflammatory role in SAT. Presence of IL‐1ra allele 2 increases the risk of developing TPOab.