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Sumatriptan increases the proliferation of peripheral blood mononuclear cells from HIV‐infected individuals and healthy blood donors in vitro
Author(s) -
Afzelius Pia,
Nielsen Jens Ole
Publication year - 2000
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2000.d01-8.x
Subject(s) - peripheral blood mononuclear cell , intracellular , immunology , cyclic adenosine monophosphate , activator (genetics) , in vitro , endocrinology , adenosine , medicine , polyclonal antibodies , biology , antigen , receptor , biochemistry
HIV infection is characterized by the loss of CD4+ T cells as well as the loss of T‐cell function, leading to severe immunodeficiency. The proliferative capacity of T cells measured in vitro as responses to antigens and mitogens is severely reduced during HIV infection. An increased level of the intracellular second messenger adenosine 3′,5′‐cyclic monophosphate (cAMP) has been shown to cause impaired proliferative capacity of peripheral blood mononuclear cells (PBMC) from HIV‐infected individuals in vitro. Sumatriptan, a 5HT1d receptor agonist, inhibits the activity of adenylyl cyclases, the enzymes responsible for regulation of the intracellular levels of cAMP. In a preliminary study sumatriptan increased the proliferative responses of PBMC to a polyclonal activator in vitro in 9 of 10 HIV‐seropositive individuals (p=0.007), and in 7 of 9 healthy blood donors (p=0.05). This was probably due to a decrease in the intracellular level of cyclic AMP.