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Well‐differentiated adenocarcinoma of the gallbladder mimicking minimal deviation adenocarcinoma of the cervix.
Author(s) -
Tashiro Takashi,
Hirokawa Mitsuyoshi,
Horiguchi Hidehisa,
Wakatsuki Shingo,
Sano Toshiaki,
Yada SEigo
Publication year - 2000
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1034/j.1600-0463.2000.d01-41.x
Subject(s) - adenomyomatosis , gallbladder , adenocarcinoma , pathology , medicine , papillary adenocarcinoma , carcinoma , lesion , differential diagnosis , cholecystectomy , columnar cell , cancer , epithelium
We report a case of well‐differentiated adenocarcinoma of the gallbladder, histologically mimicking minimal deviation adenocarcinoma (MDA) of the cervix. A 71‐year‐old Japanese male underwent cholecystectomy because of the suggestion of gallbladder carcinoma. The resected gallbladder showed a localized thickening of the gallbladder wall with a polypoid lesion measuring 12 × 7 mm in diameter. Microscopically, the polypoid lesion proved to be a well‐differentiated adenocarcinoma composed of columnar cells with a clear cytoplasm. In the thickened gallbladder wall, well‐formed glands were extensively distributed; they were surrounded by a slightly desmoplastic reaction instead of lamina propria, or were directly in contact with smooth muscle cells. The diagnostic criteria for cervical MDA may be useful in distinguishing well‐differentiated adenocarcinoma of the gallbladder from benign conditions, such as Rokitansky‐Aschoff sinus and adenomyomatosis. It is remarkable that the tumor cells of the present case expressed gastric type mucin which is characteristic of mucinous type cervical MDA.