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Change of immunoglobulins and complement factors in patients with self‐injurious behaviour
Author(s) -
Moe T. J.,
Mykletun A.,
Matre R.,
Skovlund E.,
Bassøe CF.,
Dahl A. A.
Publication year - 2003
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2003.02119.x
Subject(s) - immunocompetence , antibody , complement system , immunology , medicine , complement (music) , immunoglobulin m , immunoglobulin a , immunoglobulin g , immune system , biology , complementation , gene , phenotype , biochemistry
Objective: As stress activates the inflammatory response system, and attempted suicide is connected with severe stress, we hypothesized that patients hospitalized for self‐injurious behaviour have changed immunocompetence. Method: The concentration of immunoglobulins IgG, IgA, IgM, and the complement components C3 and C4 in 73 patients hospitalized for self‐injurious behaviour was compared with those of 122 healthy controls. The immunoglobulins and complement were quantified by nephelometric technique. Results: The levels of IgG and IgM were significantly lower, and the complement C3 and C4 were significantly higher in self‐injurious patients compared with controls. This was valid in both genders and the effects did not interact with gender. Conclusions: This controlled study showed that the concentrations of immunoglobulins were reduced and complement components were increased in patients who are admitted to hospital for self‐injurious behaviour.