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No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis
Author(s) -
Robertson E.,
Jones I.,
Middle F.,
Moray J.,
Craddock N.
Publication year - 2003
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2003.00167.x
Subject(s) - psychosis , bipolar disorder , 5 ht2a receptor , postpartum psychosis , genotype , psychiatry , childbirth , psychology , allele , medicine , clinical psychology , pregnancy , genetics , 5 ht receptor , gene , serotonin , mood , biology , receptor
Objective: To examine whether variation at two common polymorphisms, T102C and −1438AG, of the serotonin 2A gene ( 5HT2A ) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. Method: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM‐IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. Results: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. Conclusion: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.