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Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family‐based association study in the Bulgarian population
Author(s) -
Georgieva L.,
Dimitrova A.,
Nikolov I.,
Koleva S.,
Tsvetkova R.,
Owen M. J.,
Toncheva D.,
Kirov G.
Publication year - 2002
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2002.1o174.x
Subject(s) - dopamine transporter , proband , schizoaffective disorder , allele , transmission disequilibrium test , genetics , bipolar disorder , variable number tandem repeat , schizophrenia (object oriented programming) , psychiatry , psychology , medicine , haplotype , psychosis , biology , gene , mutation , cognition , transporter
Objective: A 40‐bp variable number tandem repeat in the 3′‐UTR of dopamine transporter gene ( DAT1 ) has been examined for association with major psychiatric disorders in several case–control studies. No significant results have been found. We used a new collection of parent–offspring trios to test for association with schizophrenia (SZ), bipolar 1 disorder (BPI) and schizoaffective (SA) disorder. Method: We genotyped trios from Bulgarian origin where the proband had SZ (178 trios), BPI (77 trios) and SA (29 trios). Alleles ranging from 5 to 11 repeats were observed. The results were analysed with the extended TDT (ETDT). Results: No preferential transmission of alleles was observed for any diagnostic group. The presence of allele DAT*10 was associated with the severity and frequency of auditory hallucinations, however, this result is not significant if corrected for multiple testing. Conclusion: Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.