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Genetic epidemiology: bringing genetics to the population – the NAPE Lecture 2001
Author(s) -
Merikangas K.
Publication year - 2002
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2002.01001.x
Subject(s) - epidemiology , genetic epidemiology , molecular epidemiology , population , population genetics , genetics , molecular genetics , psychiatric genetics , human genetics , witness , public health , identification (biology) , genome wide association study , psychiatry , biology , psychology , medicine , environmental health , pathology , gene , computer science , schizophrenia (object oriented programming) , genotype , single nucleotide polymorphism , programming language , botany
Objective: To present an overview of the status of genetics of mental disorders and to describe the role of genetic epidemiology in the future of the implementation of the human genome initiative. Method: Reviews evidence on familial recurrence risk for major mental disorders and approaches to identify genes for complex disorders. Results: The next decade will witness shifts in approaches of both epidemiology and genetics to address sources of complexity of the mental disorders. Descriptive genetic epidemiology will evolve into analytic genetic epidemiology by shifting the key questions from estimation of the magnitude of mental disorders to identification of risk and protective environmental factors that may be informative for both etiology and prevention. Genetics research will expand to population‐based studies for complex disorders and will employ designs and methods that incorporate sources of complexity. Conclusion: In summary, the next era of human genetics will witness major shifts in approaches to identify the genes underlying mental disorders. The contributions of genetic epidemiology to translate advances in molecular genetics to public health are discussed.