Premium
Testing the stress‐vulnerability hypothesis in ICD‐10‐diagnosed acute and transient psychotic disorders
Author(s) -
Das S. K.,
Malhotra S.,
Basu D.,
Malhotra R.
Publication year - 2001
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2001.00300.x
Subject(s) - proband , medicine , psychiatry , family history , psychology , clinical psychology , biochemistry , chemistry , mutation , gene
Objective: To examine if family‐history‐positive (FHP) vis‐à‐vis family‐history‐negative (FHN) probands with ICD‐10‐diagnosed acute and transient psychotic disorders (ATPD) differ significantly with respect to number of life events and cumulative stress score prior to the onset of ATPD. Method: Forty probands with ICD‐10‐based clinical diagnosis of acute and transient psychotic disorders were studied with respect to: (a) history of psychiatric disorders in first‐degree relatives, and (b) antecedent life events and cumulative stress. The FHP and FHN probands were compared on the latter variables using Mann–Whitney U ‐test. Results: FHP probands reported significantly less number of total life events compared to FHN probands ( P =0.006). Similarly, FHP probands had significantly less stress score than FHN probands ( P =0.002). There were no significant demographic or clinical differences between the two groups. Conclusion: The findings support the stress‐vulnerability hypothesis in the aetiology of ATPD.