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Neuromorphological abnormalities in schizophrenic patients with good andpoor outcome
Author(s) -
Rossi A.,
Bustini M.,
Prosperini P.,
Marinangeli M. G.,
Splendiani A.,
Daneluzzo E.,
Stratta P.
Publication year - 2000
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2000.900666.x
Subject(s) - ventricle , magnetic resonance imaging , schizophrenia (object oriented programming) , outcome (game theory) , temporal lobe , psychology , medicine , brain size , psychosis , cardiology , psychiatry , radiology , mathematics , mathematical economics , epilepsy
Objective: The present study was designed specifically to assess the relationship between brain morphology and outcome in schizophrenia. Methods: Fifty‐six schizophrenic patients and a matched group of 32 healthy subjects were studied with magnetic resonance (MR) imaging scans. Clinical assessment included the Krawiecka–Manchester Scale (K‐MS) and the Outcome scale by Strauss and Carpenter. Results: Along several neuromorphological measures the patients differed from controls only for right and left ventricular volumes. The ‘poor outcome’ patients had a left and right ventricular enlargement when compared to the ‘good outcome’ patients and healthy controls. A regression analysis showed that right ventricle volume, left temporal lobe volume and left hippocampal volume entered into the regression equation, accounting for a 27% of the outcome measure. Conclusion: The outcome does not seem to be predicted by one particular morphological site but involves different brain regions; however, the ventricular enlargement identifies a subgroup of patients with poor outcome.