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Brain imaging in childhood‐ and adolescence‐onset schizophrenia associated with obsessive‐compulsive symptoms
Author(s) -
Aoyama F.,
Iida J.,
Inoue M.,
Iwasaka H.,
Sakiyama S.,
Hata K.,
Kishimoto T.
Publication year - 2000
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2000.102001032.x
Subject(s) - hippocampus , schizophrenia (object oriented programming) , corpus callosum , putamen , frontal lobe , psychology , magnetic resonance imaging , etiology , neuroimaging , psychosis , obsessive compulsive , psychiatry , medicine , age of onset , neuroscience , pediatrics , radiology , disease
Objective: Childhood‐ and adolescence‐onset schizophrenic patients with obsessive‐compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence of neurodevelopmental insults. Method: Thirty‐two schizophrenic patients were compared with 19 controls. Schizophrenic subjects were divided into 15 patients with OCS (SOCS + group; onset at 15.5±1.6 years) and 17 without OCS (SOCS − group; onset at 15.3±1.3 years). Areas of the hippocampus, frontal lobe, corpus callosum and putamen were analysed morphometrically. Results: The left hippocampus was significantly smaller in the SOCS + group than in the SOCS − and control groups. Conclusion: Reduced size of the left hippocampus in the SOCS + group supports a neurodevelopmental etiology in this subgroup.