Premium
Brain noradrenaline and the mechanisms of action of antidepressant drugs
Author(s) -
Svensson Torgny H.
Publication year - 2000
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1034/j.1600-0447.2000.02604.x
Subject(s) - antidepressant , neuroscience , locus coeruleus , reuptake inhibitor , drug action , reuptake , context (archaeology) , monoamine neurotransmitter , norepinephrine , facilitation , psychology , drug , medicine , pharmacology , dopamine , serotonin , central nervous system , biology , hippocampus , receptor , paleontology
The basic mechanisms of action of presently used antidepressant drugs are still far from understood. This review will address a few critical issues in this area, namely (i) putative mechanisms underlying the delay in onset of action of monoamine reuptake inhibitors and potential limitations to the efficacy of these drugs, (ii) the significance of stress‐induced activation of the locus coeruleus noradrenergic system for the function of the mesolimbic reward system and the effect of chronic antidepressant treatment within this context and (iii) the interaction between brain noradrenaline and 5‐hydroxytryptamine systems and its significance for antidepressant drug action. Recent preclinical and clinical research which suggest novel strategies to enhance antidepressant drug efficacy will also be discussed. From this review emerges the notion that facilitation of brain noradrenergic neurotransmission may represent a more fundamental means to achieve maximal response in major depression than hitherto understood.