Open AccessVisually impaired children with posterior ocular malformations: pre‐ and neonatal data and visual functions
Author(s) -
Fahnehjelm Kristina Teär,
Jacobson Lena,
Hellström Ann,
LewensohnFuchs Ilona,
Ygge Jan
Publication year - 2003
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1034/j.1600-0420.2003.00100.x
Subject(s) - medicine , optic nerve hypoplasia , coloboma , pediatrics , retinopathy of prematurity , visual impairment , optic nerve , visual acuity , pregnancy , ophthalmology , gestational age , genetics , psychiatry , biology
. Aim: To analyse pre‐ and neonatal data and ocular findings in children with visual impairment caused by posterior ocular malformations. Methods: Medical records were scrutinized, dried blood spot cards were analysed for virus DNA and ophthalmological assessments were performed in 28 children with optic nerve hypoplasia (ONH) and 10 with optic/chorio‐retinal coloboma. Results: Prenatal exposure to possible teratogens was documented in 5/28, herpes simplex virus type 1 DNA was identified in the dried blood spot cards of 1/26 children and neonatal hypoglycaemia in 12/28 children with ONH. The time delay from ocular to endocrinological diagnosis and treatment was 3 years. Children with ONH and severe visual impairment had endocrinopathy more often (11/13) than ONH children with better visual functions (5/15). Prenatal exposure to teratogens or neonatal hypoglycaemia was not identified in any of the children with coloboma. Conclusion: Neonatal hypoglycaemia was common in children with ONH. Severe visual impairment predicted endocrinopathy. Analysis of dried blood spot cards could serve as an additional diagnostic tool in children with ocular malformations.