Open AccessDetection of cervical intraepithelial neoplasia in women with atypical squamous or glandular cells of undetermined significance cytology: A prospective study
Author(s) -
Wensveen Celesta,
Kagie Marjolein,
Veldhuizen Roel,
Groot Christianne De,
Denny Lynette,
Zwinderman Koos,
Trimbos Baptist
Publication year - 2003
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1034/j.1600-0412.2003.00231.x
Subject(s) - colposcopy , medicine , cervical intraepithelial neoplasia , koilocyte , cervix , intraepithelial neoplasia , cytology , pathology , gynecology , human papillomavirus , cervical cancer , cancer , prostate
Background. (1) To assess the prevalence of histologically confirmed cervical intraepithelial neoplasia in patients with cervical smears diagnosed as atypical squamous or glandular cells of undetermined significance. (2) To evaluate the role of colposcopy and the presence of human papillomavirus in detecting underlying cervical intraepithelial neoplasia. Materials and methods. In this prospective cohort, 148 women with atypical squamous or glandular cells of undetermined significance were evaluated by colposcopy, histological sampling, and human papillomavirus deoxyribonucleic acid testing. Results. Histological diagnosis of ≥ cervical intraepithelial neoplasia II was found in 10/148 women. Women with a histological ≥ cervical intraepithelial neoplasia II had a higher prevalence of ≥ two abnormal quadrants (90% vs. 38%≤ cervical intraepithelial neoplasia I, p = 0.002) and of high/intermediate‐risk human papillomavirus (90% vs. 42% ≤ cervical intraepithelial neoplasia I, p = 0.005). Conclusion. Our study shows that premalignant lesions of the cervix were present in 7% of the patients with a cytological diagnosis of atypical squamous or glandular cells of undetermined significance. Colposcopy and human papillomavirus deoxyribonucleic acid testing are both important parameters in detecting ≥ cervical intraepithelial neoplasia II.