Open AccessSerum leptin levels in pregnant women with type 1 diabetes mellitus
Author(s) -
Lauszus Finn F.,
Schmitz Ole,
Vestergaard Henrik,
Klebe Joachim G.,
Pedersen Oluf
Publication year - 2001
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1034/j.1600-0412.2001.800702.x
Subject(s) - medicine , leptin , endocrinology , pregnancy , glycemic , blood pressure , diabetes mellitus , birth weight , adipose tissue , gestational diabetes , obesity , gestation , biology , genetics
Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta. Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant changes in maternal body weight, birth weight, glycemic control, and blood pressure. Methods. Non‐fasting serum leptin from 45 women with type 1 diabetes mellitus were studied consecutively throughout pregnancy and 3 months post partum. Results. Serum leptin was positively associated with HbA1c in week 18, 22 and 30 (r=0.38, 0.41, and 0.54, respectively, p <0.05, adjusted for body weight). Moreover, serum leptin correlated positively with maternal body weight and BMI (0.4525 kg/m 2 ), the changes during pregnancy and the level of serum leptin were significantly greater compared to lean women ( p <0.05). The women with low ambulatory blood pressure (lower tertile, mean arterial blood pressure <83.4 mmHg) showed the lowest level of serum leptin throughout pregnancy and it changed significantly differently from the women with higher blood pressure ( p <0.05). Conclusion. Changes in serum leptin levels of pregnant women with type 1 diabetes mellitus were associated with parallel changes in maternal body weight and glycemic control. Women with low blood pressure had the lowest serum leptin levels throughout pregnancy.