Open AccessOral guar gum, a gel‐forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy
Author(s) -
RIIKONEN SEIJA,
SAVONIUS HANNELE,
GYLLING HELENA,
NIKKILÄ KATRIINA,
TUOMI ANNAMAIJA,
MIETTINEN TATU A.
Publication year - 2000
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1034/j.1600-0412.2000.079004260.x
Subject(s) - medicine , guar gum , cholestasis of pregnancy , dietary fiber , pregnancy , cholestasis , guar , gastroenterology , food science , fetus , pathology , chemistry , biology , genetics
Background. Guar gum is a gel‐forming fiber, which increases fecal elimination of bile acids. It may therefore be beneficial in the treatment of intrahepatic cholestasis of pregnancy. Methods. Forty‐eight patients with intrahepatic cholestasis of pregnancy were randomized double‐blind to receive either guar gum or placebo until delivery. Serum bile acid concentration was measured. Pruritus was assessed by both the investigator and the patient. Results. At baseline, the intensity of pruritus and the serum bile acid concentration were significantly related. Guar gum diminished or prevented worsening of pruritus, while in the placebo group pruritus was enhanced ( p <0.05). In the placebo group serum bile acid concentration increased significantly, whereas in the guar gum group it remained unchanged ( p <0.05 between the groups). Guar gum treatment‐induced changes of the pruritus score and serum bile acid concentrations were significantly related ( p <0.01). Conclusions. Guar gum relieved the intensity of pruritus without any side effects and prevented the rise in serum bile acid concentration in this placebo‐controlled and double‐blind study of patients with intrahepatic cholestasis of pregnancy.