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Platelet serotonin transporter in stroke patients
Author(s) -
Rasmussen A.,
Christensen J.,
Clemmensen P. M.,
Dalsgaard N. J.,
Dam H.,
Hindberg I.,
Lunde M.,
Plenge P.,
Mellerup E.
Publication year - 2003
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2003.02053.x
Subject(s) - serotonin transporter , serotonin , stroke (engine) , platelet , depression (economics) , medicine , serotonin plasma membrane transport proteins , transporter , anesthesia , biology , receptor , biochemistry , gene , mechanical engineering , engineering , economics , macroeconomics
Objectives – Post‐stroke depression can be treated with serotonin transport inhibitors suggesting a role for the serotonin system in these patients. The number of platelet serotonin transporters in stroke patients and in control subjects have been measured in this study. Materials and methods – Newly admitted stroke patients who did develop or who did not develop a post‐stroke depression, non‐acute patients who previously had had a stroke and control subjects were compared. The number of platelet serotonin transporters was analysed by ligand binding methodology. Results – The number of platelet serotonin transporters was low shortly after a stroke compared with normal subjects; no difference was found between the stroke patients who developed a post‐stroke depression and those who did not. Conclusion – A low number of platelet serotonin transporters may be a non‐specific state marker for a condition as acute stroke.