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Effect of apolipoprotein E genotype on in‐hospital mortality following intracerebral haemorrhage
Author(s) -
McCarron M. O.,
Weir C. J.,
Muir K. W.,
Hoffmann K. L.,
Graffagnino C.,
Nicoll J. A. R.,
Lees K. R.,
Alberts M. J.
Publication year - 2003
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2003.01365.x
Subject(s) - medicine , apolipoprotein e , intracerebral hemorrhage , allele , genotype , stroke (engine) , pediatrics , biology , genetics , disease , gene , mechanical engineering , subarachnoid hemorrhage , engineering
Objective – To determine the relationship between the apolipoprotein E ( APOE ) ε 4 allele and in‐hospital mortality from intracerebral haemorrhage (ICH). Material and methods ‐‐ Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In‐hospital survival was recorded in 176 patients. Results – There were 85 men and 91 women, mean age 68 years. Fifty‐two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age ( P = 0.009) and the presence of the APOE ε 4 allele ( P = 0.026) significantly reduced in‐hospital survival. Conclusion – The APOE ε 4 allele in this population may be associated with poor survival following ICH.