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Unchanged striatal dopamine transporter availability in narcolepsy: a PET studywith [ 11 C]‐CFT
Author(s) -
Rinne J. O.,
Hublin C.,
Någren K.,
Helenius H.,
Partinen M.
Publication year - 2004
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2003.00175.x
Subject(s) - narcolepsy , putamen , caudate nucleus , dopamine transporter , dopamine , radioligand , medicine , endocrinology , positron emission tomography , psychiatry , nuclear medicine , neurology , receptor , dopaminergic
Objective – To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy. Patients and methods – Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [ 11 C]‐CFT was used as a radioligand. Results – The uptake of[ 11 C]‐CFT was within normal limits (89% of age‐adjusted control mean in the caudate nucleus and 91% in the putamen) in patientswith narcolepsy. Conclusion – No evidence of altered striataldopamine transporter availability was found in narcolepsy.