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A case of Kleine–Levin syndrome examined with SPECT and neuropsychological testing
Author(s) -
Landtblom A.M.,
Dige N.,
Schwerdt K.,
Säfström P.,
Granérus G.
Publication year - 2002
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2002.1c162.x
Subject(s) - neuropsychology , temporal lobe , psychology , frontal lobe , perfusion , verbal memory , neuropsychological assessment , medicine , audiology , nuclear medicine , neuroscience , radiology , epilepsy , cognition
A case of Kleine–Levin syndrome with typical periodic hypersomnia and bulemia was diagnosed. On examination with single photo emission tomography (SPECT) (CERETEC ® ) during a relapse period and 2 weeks later there was marked cortical hypoperfusion of the frontal and temporal lobes, especially on the left side as well as in the right parietal lobe. Neuropsychological testing performed 1 week after a relapse showed a reduction in encoding to memory function of verbal learning indicating neocortical damage of the left fronto‐temporal region. A follow‐up 2 months later after the patient had spontaneously recovered showed only a slight left fronto‐temporal disturbance. CT and MRI of the brain were normal although the MRI showed a large and asymmetric mamillary body. Neuropsychological testing 6 years after recovery showed pronounced reduction in short‐time verbal and visual memory. Seven years after recovery SPECT demonstrated a normalized frontal perfusion but still a slight hypoperfusion in the left temporal lobe. Our results correlate to autopsy findings in two cases described previously.