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Beta‐CIT‐SPECT combined with UPDRS appears to distinguish different parkinsonian conditions
Author(s) -
Sjøholm H.,
Sundsfjord J.,
Mellgren S. I.
Publication year - 2002
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2002.0o363.x
Subject(s) - parkinsonism , medicine , parkinson's disease , rating scale , single photon emission computed tomography , central nervous system disease , beta (programming language) , disease , degenerative disease , nuclear medicine , physical therapy , psychology , developmental psychology , computer science , programming language
Objectives – An earlier study in l ‐dopa responding patients with idiopathic Parkinson's disease documented that progressive nigro‐striatal degeneration shown with single photon emission computed tomography (SPECT) and the cocain analog iodine‐123‐beta‐CIT (beta‐CIT) correlated linearly with increasing motor scores in the Unified Parkinson's Disease Rating Scale (UPDRS). Here we have extended the study to include 2 tremor patients with mild parkinsonism, 2 poor l ‐dopa responders with parkisonism and 2 non l ‐dopa responders with severe parkinsonism. Methods – SPECT scanning was performed 20 h after injection of beta‐CIT and UPDRS was done at the time of beta‐CIT injection. Results – All patients in the present study showed less nigro‐striatal degeneration in relation to UPDRS motor scores than the patients with idiopathic Parkinson's disease. Conclusion – The results suggest that the the combination of beta‐CIT‐SPECT and UPDRS motor scores has the potential to differentiate idiopathic Parkinson's disease from other parkinsonian conditions.