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Association of platelet hyper‐aggregability with leukoaraiosis
Author(s) -
Fujita S.,
Kawaguchi T.
Publication year - 2002
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2002.01208.x
Subject(s) - leukoaraiosis , medicine , platelet , hematocrit , cardiology , risk factor , platelet aggregation , gastroenterology , dementia , disease
Objectives – To investigate whether there is any relationship between leukoaraiosis and platelet hyper‐aggregability of the systemic blood. Methods – Platelet aggregability, leukoaraiosis, hypertension and hematocrit were assessed in 175 consecutive out‐patients attending a regular clinic. Platelet aggregability was estimated by an optical analytical method using two different concentrations each of ADP and collagen (the double ADP method). Hyper‐aggregability and non hyper‐aggregability were defined with this method. Results – Patients with leukoaraiosis (73 cases) showed a significantly higher incidence of platelet hyper‐aggregability than patients with no leukoaraiosis (102 cases) (90.4 vs 56.9%, P =0.1). Leukoaraiosis was also significantly related to age. Hypertension was a less significant risk factor ( P =0.023). Conclusions – Platelet hyper‐aggregability is a significant feature in leukoaraiosis, and appears to be a more important risk factor than hypertension. Normalization of platelet hyper‐aggregability might offer an alternative strategy for the prevention of leukoaraiosis in patients with platelet hyper‐aggregability, although an interventional study is essential.