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Butyrylcholinesterase in lumbar and ventricular cerebrospinal fluid
Author(s) -
Kluge W. H.,
Kluge H. H.,
Hochstetter A.,
Vollandt R.,
Bauer H. I.,
Venbrocks R.
Publication year - 2001
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2001.00286.x
Subject(s) - butyrylcholinesterase , cerebrospinal fluid , lumbar , lumbar puncture , medicine , chemistry , anesthesia , aché , enzyme , acetylcholinesterase , biochemistry , surgery
Objectives – This study establishes reference data for human lumbar CSF butyrylcholinesterase (E.C.3.1.1.8.) activity and investigates the enzyme activity in ventricular CSF. We comment on the relationship between CSF butyrylcholinesterase activity and other laboratory parameters. Subjects and methods – We investigated 64 lumbar CSF samples obtained from a clinically healthy population and 169 ventricular CSF samples collected from 90 neurosurgical patients. Results – The reference range we recommend for lumbar CSF butyrylcholinesterase activity is 5.4 to 17.0 nmol/min×ml. The majority of ventricular butyrylcholinesterase activities in our patient subset ranged up to 5 nmol/min×ml. Conclusions – We established the relative influence of serum and CNS components on total CSF butyrylcholinesterase activity. The CNS fraction predominates the total butyrylcholinesterase activity in normal lumbar CSF. In ventricular CSF enzyme influx from serum outweighs the CNS component.