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Loco‐regional thrombolysis in the treatment of cerebral venous and sinus thrombosis: report of two cases
Author(s) -
Buccino G.,
Scoditti U.,
Pini M.,
Menozzi R.,
Piazza P.,
Zuccoli P.,
Mancia D.
Publication year - 2001
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2001.00058.x
Subject(s) - thrombolysis , medicine , cerebral venous sinus thrombosis , urokinase , heparin , thrombosis , surgery , venous thrombosis , anesthesia , myocardial infarction
Although intravenous (i.v.) heparin is widely used as the first line treatment for cerebral venous and sinus thrombosis (CVST), the most appropriate therapy for this disease is still controversial. We report 2 cases of CVST who were successfully treated by means of loco‐regional thrombolysis with urokinase. In the first case we chose this treatment instead of i.v. heparin because clinical conditions of the patient appeared critical for life on hospital admission; in the second case loco‐regional thrombolysis was performed because a full‐dose heparin treatment over 8 days failed to improve the clinical picture of the patient. In the literature, there are no established criteria for the use of loco‐regional thrombolysis in CVST. On the basis of our own experience and few previous reports on the matter, we suggest that loco‐regional thrombolysis should be considered an appropriate treatment for CVST when patients are at life risk, when an involvement of deep cerebral veins is present or when, after full heparinization, patients are doing poorly clinically.