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Elevation of neuron‐specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt–Jakob disease
Author(s) -
Kohira I.,
Tsuji T.,
Ishizu H.,
Takao Y.,
Wake A.,
Abe K.,
Kuroda S.
Publication year - 2000
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2000.102006385.x
Subject(s) - enolase , cerebrospinal fluid , medicine , stage (stratigraphy) , gastroenterology , pathology , biology , immunohistochemistry , paleontology
Objective – To investigate the levels of neuron‐specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of patients with early stage Creutzfeldt–Jakob disease (CJD). Methods – The levels of NSE in serum and CSF were examined in 6 cases with CJD patients. The levels of NSE in CSF were measured in 8 age matched control patients with other neurological diseases and the levels of serum NSE were also measured in another 8 age matched control patients with other neurological diseases. The groups of 8 age matched control patients consisted of 1 same patient and 7 different patients in the 2 control groups both for serum and CSF. Results – The level of serum NSE in CJD (17.3±7.0 ng/ml, mean±SD) was significantly higher than that of controls (6.5±1.6) ( P <0.02) as was the case in CSF (79.3±53.3 ng/ml) vs (9.6±2.9) ( P <0.03). Conclusion – Although mean NSE levels of CJD were higher in CSF than in the serum, there still is a case with higher serum NSE level than CSF. These results suggest that the mechanism of elevation of serum NSE may not be a simple leakage from CSF, and that the measurement of serum NSE level may be useful for diagnosis of early stage CJD.