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Is Campylobacter lipopolysaccharide bearing a GD3 epitope essential for the pathogenesis of Guillain–Barré syndrome?
Author(s) -
Yuki N.,
Koga M.,
Hirata K.
Publication year - 2000
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2000.102002132.x
Subject(s) - campylobacter jejuni , guillain barre syndrome , medicine , immunology , antibody , serology , enteritis , pathogenesis , diarrhea , lipopolysaccharide , gastroenterology , biology , bacteria , genetics
The hypothesis has been proposed that the GD3 ganglioside‐like lipopolysaccharide (LPS) is essential for and functions in the development of Guillain–Barré syndrome (GBS) and Miller Fisher syndrome (MFS) subsequent to Campylobacter jejuni enteritis. Our study showed that patients with GBS or MFS who had previously suffered diarrhea had anti‐GD3 antibodies less often than those who had not had diarrhea. Sera from patients who showed GBS or MFS with the serologic evidence of prior C. jejuni infection had anti‐GD3 antibodies less frequently than sera from those without evidence of infection. Statistical analysis showed that anti‐GD3 antibodies were less frequent in patients with GBS or MFS from whom C. jejuni had been isolated than were other anti‐ganglioside antibodies, such as anti‐GM1 antibodies. These results could not support the above hypothesis.