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Serum levels of coenzyme Q 10 in patients with multiple sclerosis
Author(s) -
De Bustos F.,
JiménezJiménez F. J.,
Molina J. A.,
GómezEscalonilla C.,
De Andrés C.,
Del Hoyo P.,
Zurdo M.,
TallónBarranco A.,
Berbel A.,
PortaEtessam J.,
Parrilla G.,
Arenas J.
Publication year - 2000
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1034/j.1600-0404.2000.101003209.x
Subject(s) - coenzyme q10 , multiple sclerosis , coenzyme q – cytochrome c reductase , medicine , disease , risk factor , endocrinology , gastroenterology , chemistry , immunology , biochemistry , cytochrome c , mitochondrion
To elucidate whether serum coenzyme Q 10 levels are related with the risk for multiple sclerosis (MS) or are a marker for the activity of the disease, we compared serum levels of coenzyme Q 10 and the coenzyme Q 10 /cholesterol ratio, in 31 patients with MS (during exacerbations) and 19 matched controls using a high performance liquid chromatography technique. The mean serum coenzyme Q 10 levels and the coenzyme Q 10 /cholesterol ratio did not differ significantly between the 2 study groups. The values did not correlate with age, age at onset, and duration of the disease. These results suggest that serum coenzyme Q 10 concentrations are unrelated with the risk for MS and are not a useful marker of activity of the disease.