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The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end‐stage liver disease
Author(s) -
Zeh Nina,
Rossi Steven S.,
Hofmann Alan F.,
Steinbach Joseph H.,
Hagey Lee R.,
Oliver Deanna,
Stange Jan,
Hassanein Tarek
Publication year - 2003
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1034/j.1478-3231.23.s.3.11.x
Subject(s) - albumin , polyunsaturated fatty acid , phospholipid , medicine , liver disease , chemistry , fatty acid , dialysis , gastroenterology , biochemistry , membrane
The effect of extracorporeal albumin dialysis (ECAD) using the MARS™ device on plasma phospholipid fatty acids (PLFA) in patients with end‐stage liver disease (ESLD) was examined. Phospholipids were isolated from plasma and the fatty acid (FA) composition of non‐sphingomyelin PL determined using capillary gas chromatography (GC). Plasma samples were also obtained from six patients with ESLD undergoing ECAD and from five patients with similar ESLD who were not treated, as well as from non‐fasting healthy subjects. PLFA were much lower [506 ± 62 μg/mL ( M ± SD)] in patients with ESLD than in healthy subjects (2709 ± 688 μg/mL). In addition, the proportion of n 3 and n 6 polyunsaturated FA was much lower in patients with ESLD ( n 3, 1.7 ± 0.1%, n 6, 19.6 ± 1.4%) than in healthy controls ( n 3, 4.1 ± 2.4%, n 6, 31.9 ± 6.2%) ECAD caused an immediate increase in PLFA, averaging 56% in all patients, but PLFA levels decreased some hours later after treatment. ECAD also caused a small increase in the proportion of n 3 and n 6 of PLFA. During the 5 days of the study, PLFA rose in both ECAD‐treated and untreated patients, but the increase was significantly greater in ECAD treated patient. It is concluded that patients with ESLD have markedly decreased PLFA; these PLFA have a lower proportion of the polyunsaturated n 3 and n 6 FA with the result that the plasma level of these essential polyunsaturated PLFA is extremely low compared to that of healthy subjects. ECAD causes a transient increase in PLFA toward normal levels and also increases the proportion of n 3 and n 6 FA.