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Between Scylla and Charybdis: A bleomycin‐exposed patient with Cohen syndrome
Author(s) -
OrbachZinger S.,
Kaufman E.,
Donchin Y.,
Perouansky M.
Publication year - 2003
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2003.00169.x
Subject(s) - medicine , ards , bleomycin , respiratory distress , acute respiratory distress , anesthesia , airway , pulmonary function testing , chemotherapy , intensive care medicine , lung
Chemotherapy with bleomycin may cause a syndrome of pulmonary sensitivity to supranormal inspired oxygen concentrations that persists for an unknown period of time after exposure. We present a mentally retarded adolescent patient in whom supranormal inspired oxygen was temporarily necessary to manage her difficult airway. Subsequently her pulmonary function deteriorated acutely and, after intermittent stabilization, irreversibly. In this case, bleomycin exposure may have played a pivotal role in modulating minor insults to trigger fatal acute respiratory distress syndrome (ARDS).