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Inhibitory effects of desflurane and sevoflurane on contractions of isolated gravid rat myometrium under oxytocin stimulation
Author(s) -
Dogru K.,
Yildiz K.,
Dalgiç H.,
Sezer Z.,
Yaba G.,
Madenoglu H.
Publication year - 2003
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2003.00087.x
Subject(s) - desflurane , sevoflurane , oxytocin , medicine , anesthesia , myometrium , stimulation , inhibitory postsynaptic potential , endocrinology , uterus
Background: We studied the inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated gravid rat myometrium. Methods: Twenty strips were obtained from rats and these were randomly assigned into two groups. The effects of desflurane and sevoflurane were evaluated by treating strips with oxytocin alone 2×10 −9 M or with oxytocin after desflurane and sevoflurane at 0.5, 1, and 2 MAC. Results: Oxytocin significantly increased the amplitude and duration of contractions (P< 0.05), but it did not increase the frequency. The duration (84%, 79%), amplitude (90%, 84%) and frequency (88%, 75%) were inhibited at 2 MAC of desflurane and sevoflurane, respectively. Conclusion: These results suggest that the in vitro application of desflurane and sevoflurane similarly inhibit oxytocin‐induced myometrial contractions of gravid rat in a dose‐dependent manner.