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Propofol pharmacokinetics in a dwarfism patient
Author(s) -
Tsubokawa T.,
Yamamoto K.,
Komuro A.,
Ishizuka S.,
Kobayashi T.
Publication year - 2003
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2003.00074.x
Subject(s) - supine position , medicine , propofol , prone position , pharmacokinetics , anesthesia , weakness , surgery
Pharmacokinetic information is important to control anesthetic depth. However, there are few available pharmacokinetic data of propofol in dwarfism patients. We anesthetized a dwarfism patient who underwent spinal decompression, and investigated the pharmacokinetics of propofol. The patient was a 40‐year‐old man suffering from muscle weakness and numbness in the arms. The operation consisted of two stages; anterior approach in the supine position and posterior approach in the prone position. We also obtained arterial blood for pharmacokinetic analysis. Distribution volume at steady‐state and clearance in the supine position was 180 and 0.92 l min − 1 , respectively, and in the prone position 127 and 0.74 l min − 1 , respectively, in spite of a continuous infusion of dopamine. The data in the supine position were well predicted by Gepts' parameters (used in Diprifusor ® Zeneca Ltd, Cheshire, UK), which means the target‐controlled infusion (TCI) technique can be available in the supine position, while attention is necessary to avoid overdosing when a patient is placed in the prone position.