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Glyburide decreases myocardial oxygen pressure in dogs
Author(s) -
Hoffman W. E.,
Albrecht R. F.,
Jonjev Z. S.
Publication year - 2003
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2003.00039.x
Subject(s) - medicine , oxygen pressure , oxygen , cardiology , anesthesia , organic chemistry , chemistry
Background: Reports show that glyburide, an adenosine triphosphate sensitive potassium (K + ATP ) channel blocker, will reverse the myocardial protective effect of inhalational anesthesia. We evaluated the effect of glyburide on myocardial tissue oxygen pressure (PmO2) in dogs anesthetized with desflurane. Methods: Twelve dogs were anesthetized with 8% end‐tidal desflurane for baseline anesthesia. A flow probe was placed on the left anterior descending (LAD) artery. A probe that measured PmO2 was inserted into the middle myocardium in the LAD region. After baseline measures, six dogs received i.v. 1 mg kg −1 of glyburide and six dogs received sham vehicle treatment. After the glyburide or sham treatment, each dog received an i.v. infusion of adenosine 0.1 µg kg −1 ·min −1 , sodium nitroprusside (SNP) 2–4 µg kg −1 ·min −1 and 14% end‐tidal desflurane in random order. Results: Glyburide decreased LAD artery flow from 59 ± 9 ml min −1 to 30 ± 6 ml min −1 ( P < 0.05) and PmO2 from 44 ± 16 mmHg to 30 ± 9 mmHg ( P < 0.05). Adenosine infusion increased LAD artery blood flow 180% in the sham‐treated dogs but produced no change in the glyburide‐treated dogs. Sodium nitroprusside infusion increased LAD artery flow and decreased PmO2 in both the glyburide‐ and sham‐treated dogs. Desflurane (14%) did not reverse the glyburide‐induced vasoconstriction but increased PmO2 to 38 ± 20 mmHg ( P < 0.05). Conclusion: Glyburide produced myocardial tissue hypoxia, which was not changed by adenosine, worsened by SNP and improved by 14% desflurane. The improvement in PmO2 with desflurane occurred without a change in myocardial blood flow.