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Sevoflurane low‐flow anaesthesia: best strategy to reduce Compound A concentration
Author(s) -
Di Filippo A.,
Marini F.,
Pacenti M.,
Dugheri S.,
Focardi L.,
Novelli G. P.
Publication year - 2002
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2002.460815.x
Subject(s) - sevoflurane , soda lime , medicine , anesthesia , potassium hydroxide , in vivo , potassium , sodium hydroxide , carbon dioxide , chromatography , chemistry , organic chemistry , microbiology and biotechnology , biology
Background: To define the best strategy to reduce Compound A production in Sevoflurane low‐flow anaesthesia by experiments in vitro and in vivo of different absorbers and different anaesthesia machines. Methods: In vitroCompound A has been measured at 45°Cin vitrofollowing Sevoflurane interactions with potassium hydroxide, sodium hydroxide, soda lime, Dragersorb 800 Plus and Amsorb, a new absorber that does not contain sodium or potassium hydroxide.In vivo Compound A concentration in the anaesthesia circuit (inspiratory branch) has been measured using an indirect sampling method through absorber vials (SKC) with active coal granules, during low flows (500 ml/min) general anaesthesia using soda lime, Dragersorb 800 Plus or Amsorb as absorber. Compound A was also measured during low flows (500 ml/min) general anaesthesia using as carbon dioxide absorber soda lime with different anaesthesia machines. Results: In vitroat 45°C Compound A concentration with soda lime and Dragersorb 800 Plus was about 10 times higher than with Amsorb.In vivo the Compound A concentrations in the inspiratory branch of the circuit were lower in the group with Amsorb. Conclusion: The Compound A production is minimal with Amsorb as carbon dioxide absorber.